Synthetic & Bio-organic Chemistry

Research profile

Prof. Romano Orru

The Bio-organic Chemistry research group focuses on efficient synthetic methodology employing one-pot processes. The methodology is applied to the diversity-oriented synthesis (DOS) of small focused libraries of fine-chemicals with a high added value, like building blocks for medicines or ligands for catalysis.

We use multicomponent reactions which combine multiple simple reagents to form a single product allowing molecular complexity and diversity to be created by formation of several covalent bonds in one-pot transformations. These reactions proceed with high atom and step economy minimizing the number of functional group manipulations towards a given complex molecular target and avoiding the use of protective groups.