Key publications

Cromm PM, Schaubach S, Spiegel J, Fürstner A, Grossmann TN, Waldmann H. Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides. Nat. Commun. 7, 11300 (2016).

Lee CU, Hahne G, Hanske J, Bange T, Bier D, Rademacher C, Hennig S, Grossmann TN. Redox modulation of PTEN phosphatase activty by hydrogen peroxide and bisperoxidovanadium complexes. Angew. Chem. Int. Ed. 54, 13796–13800 (2015).

Pelay-Gimeno M, Glas A, Koch O, Grossmann TN. Structure-based design of inhibitors of protein‒protein interactions: Mimicking peptide binding epitopes (review). Angew. Chem. Int. Ed. 54, 8896–8927 (2015).

Brauckhoff N, Hahne G, Yeh JTH, Grossmann TN. Protein-templated peptide ligation. Angew. Chem. Int. Ed. 53, 4337–4340 (2014).

Glas A, Bier D, Hahne G, Rademacher C, Ottmann C, Grossmann TN. Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein‒protein interaction. Angew. Chem. Int. Ed. 53, 2489–2493 (2014).