Romano Orru receives NWO-ECHO grant for one-pot syntheses of medicines

The funding of €260k enables him to strengthen his research line on the production of drug-like molecules with novel and ultra-short one-pot synthetic routes using isocyanides as alternative C1-building blocks.

01/17/2018 | 3:08 PM

The development and production of pharmaceuticals consumes large quantities of natural resources and is often far from sustainable. Especially the production of complex biologically active molecules and active pharmaceutical ingredients (APIs) is energy consuming and generates many waste like solvents and separation agents.

Therefore, it is crucial to design and develop sustainable synthetic manufacturing processes. Professor Orru (Synthetic & Bio-Organic Chemistry): “We believe that using simple C1 building blocks and developing them into common reagents and catalysts for one-pot synthesis procedures improves the overall eco-balance in pharmaceutical manufacturing.”

PhD student

The awarded ECHO grant enables funding for a PhD in this area. Orru enthusiastically claims: “This is exciting research. The PhD student in this project will work in a stimulating and challenging environment and will receive top training in synthetic chemistry of the 21st century.”

About Romano Orru’s research group

Romano Orru has a longstanding reputation on multicomponent and one-pot syntheses. His group, the AIMMS Synthetic & Bio-Organic Chemistry research group (Dept. of Chemistry & Pharmaceutical Sciences), combines sustainable synthetic methodologies with so-called one-pot processes: successive chemical reactions in one reactor. This strategy reduces the formation of side-products and enhances the chemical yield. They synthesize fine chemicals with a high added value, like building blocks for medicines or ligands for catalysis.

More information

For more information, please visit the website of the Synthetic & Bio-Organic Chemistry research group.