AIMMS mini symposium
2020-10-02 AIMMS mini symposium
STAR PLUS PhD students
Amsterdam Institute of Molecular and Life Sciences
Conference / Symposium / Seminar
During the online mini symposium AIMMS's STAR PLUS PhD students will give an update on their ongoing research projects. The PhD students all work in the field of antibiotic resistance and development. They are trying to increase the understanding of resistance development and to find new antibiotic targets.
10.00 – 10.30 Felix Paulussen
10.30 – 11.00 Priyaka Chauhan
11.00 – 11.15 Mini break
11.15 – 11.45 Alicia Berkvens
Priyanka Chauhan PhD student:Development of molecular strategies to quantify the dormant and active state of mycobacterium
The presence of subpopulation of non-growing, or dormant cells during tuberculosis infections is an immense problem. These cells persist antibiotic treatment and hence, cause treatment failure and recalcitrant infections. Since, these cells are present in very small number, their isolation and study become very difficult. I will present a simple dye-based detection and isolation technique for persisters, which can be utilized to quantify persister subpopulations of mycobacteria.
Alicia Berkvens PhD student: Exploring the Link Between Growth Regulation and Persister Formation
About 1 in 10^4 cells in an E. coli population has switched to a non-growing persister phenotype. These cells don’t grow, but can withstand harsh stresses. So when a population is faced with a stressor killing all growing cells, persisters will survive and when they switch back to the normal phenotype they can form a growing population again. Since persisters can survive antibiotic treatment, they have an increased risk of obtaining antibiotic resistance mutations. To combat the resistance crisis it is thus crucial to understand how these persisters are formed. How is it possible that from an isogenic population of cells, all exposed to the same conditions, some will switch to a dormant state? Through small computational models I explore this question and I will share how persister formation is linked to E. coli’s growth regulation.
Topic: COFUND mini symposium
Time: Oct 2, 2020 10:00 AM Amsterdam
Join Zoom Meeting
If you would like to attend the mini symposium, you can send an email to: Cofund@aimms.vu.nl. The access code will be sent to you by email.
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This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 713669.