Seminar: NVBMB Speaker of the Year

09/14/2017

16.00 - 17.00h

Auditorium, O|2 Lab Building

Seminar: NVBMB Speaker of the Year: 3-D Systems Architecture of a Bacterial Cell Cycle

Prof. Lucy Shapiro (Developmental Biology, Stanford University School of Medicine)

Amsterdam Institute for Molecules, Medicines and Systems

Sciences

Seminar

Shapiro_Lucy_2Prof. Lucy Shapiro (Department of Developmental Biology, Stanford University School of Medicine) will provide a seminar on 14 September entitled '3-D Systems Architecture of a Bacterial Cell Cycle'. She has been invited as speaker of the year by the Dutch Society for Biochemistry and Molecular Biology (NVBMB) because of her groundbreaking work on the bacterial cell cycle.

You are all cordially invited! Drinks afterwards.

Abstract

The cell cycle control logic in Caulobacter drives an integrated system that operates in time and space. Oscillating levels of temporally-controlled master regulators enable multiple cell cycle functions. Cell cycle regulation is, to a striking degree, a whole cell phenomenon with transcriptional circuitry interwoven with the 3-D deployment of phospho-signaling, which monitors the topology of the cell and is central to establishing asymmetric cell division. The overall regulatory ‘wiring diagram’ incorporates changes in DNA methylation state that enhance system robustness.

Prof. Lucy Shapiro

Lucy Shapiro is a Professor in the Department of Developmental Biology at Stanford University School of Medicine where she holds the Virginia and D. K. Ludwig Chair in Cancer Research and is the Director of Stanford’s Beckman Center for Molecular & Genetic Medicine. By studying the regulation of the cell cycle, asymmetric cell division, and cellular differentiation, Shapiro's pioneering work has led to a deep understanding of the genetic and molecular processes that cause identical bacterial cells to split into different cell types. These are basic processes that underlie all life, from single-cell bacteria to multi-cellular organisms. Her ideas have helped to develop novel drugs to fight antibiotic resistance and emerging infectious diseases. Lucy Shapiro has been actively involved in translating academic research on combatting infectious diseases to industry and has advised multiple US governments.